The very best video output for all systems is IMO achieved by using the default core options with the scanline overlay and sharp-bilinear filter. This will give you a clean image with scanlines, similar to using an XRGB-Mini.
go to settings -> overlay settings -> effects -> wii -> scanlines.cfg
go to options -> shader options -> shader passes and select “1”. Go to shader 0 and select “sharp-bilinear.” Go to shader 0 filter and select linear. Select apply settings.
make sure your scaling is correct! Enable integer scaling if you haven’t. You should immediately be able to tell if scaling is correct by just looking at some small text – some pixels will be warped/distorted as a result of bad scaling. The scanline overlay makes it easy to detect bad scaling, as the scanlines should always line up with pixel edges.
Enhanced smoothing is the devil, you’re losing detail and introducing artifacts into the image, which is bad 
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Hello and thank you for this. I will try these settings tonight.
Your post reminded me also that I changed my config to say Video Smooth =True.
I’ll ammend this and see if any of the above gives me what I am hoping to achieve.