While you are changing settings in runtime, they are not saved to disk afterwards on PC by default. If you want RetroArch to automatically write back the config, either set config_save_on_exit = true in config, or enable this under Settings -> Config Save On Exit from within RGUI.

I make the save on exit to yes but the change does not stay permanent. Upon loading again, the settings are reverted back to default.
What’s the simplest way to get to:

“config_save_on_exit = true”